The RSK2 kinase is a downstream effector of the Ras/Raf/MEK/ERK pathway that is aberrantly active in a range of cancer types and has been recognized an anticancer target.The inhibition of RSK2 kinase activity would disrupt multiple pro-cancer processes; however, there are few RSK2 inhibitors.The data have been obtained for a series of pteridinone-,

The group sequential design has been well understood and widely applied in designs of late phase clinical trial to enable potentially early stopping for efficacy or futility.The information fraction (IF) is one of the key elements to POS determine the decision boundary at the interim analyses.The family-wise error rate (FWER) control is highly crit

Tuberculosis (TB) remains the most frequent cause of illness and death from an infectious agent, and its interaction with HIV has devastating effects.We determined plasma levels of dehydroepiandrosterone (DHEA), its circulating form DHEA-suphate (DHEA-s) and cortisol in different stages of M.tuberculosis infection, and explored their role on the Th

Abstract Date bars are energy-dense snack foods developed from dried date fruits and sometimes enriched with other ingredients.They are popular functional foods for people who are looking for healthy snack options.Date bars can be fortified with different nutritional sources to overcome nutritional deficiencies among consumers.The present study was